Search Results - jay+hesselberth

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The recent introduction of mRNA vaccines has shown the tremendous clinical potential of RNA therapeutics. Unfortunately, most RNA therapeutics have struggled to make clinical progress because of their inherent instability. Many RNA therapies have failed to progress through clinical trials because they are rapidly broken down after administration....

Published: 8/29/2022 | Inventor(s): Jeffrey Kieft, Erich Chapman, David Costantino, Jay Hesselberth, Andrea MacFadden, Benjamin Akiyama

Disease Areas Infectious Disease

Category(s): Therapeutics

Measuring Functional Heterogeneity Among Single Cells

New methods to study heterogeneity at cellular resolution in complex tissues are rapidly transforming our understanding of cellular heterogeneity in human tissues and disease. However, their reliance on measurements of steady-state abundance of DNA, RNA, and protein limits our ability to extract dynamic information from single cells. Dr. Jay Hesselberth...

Published: 5/11/2023 | Inventor(s): Jay Hesselberth, Amanda Richer

Disease Areas Oncology

Category(s): Research Tools

Molecular tracking devices for measuring dissemination in tissue in vivo

Background: The dissemination of molecules through tissue establishes signaling gradients that drive complex developmental patterns, enables rapid responses to infection, and dictates the distribution of therapeutic drugs. However, our understanding of this molecular cartography would be vastly improved by charting molecular traffic throughout organ...

Published: 8/29/2022 | Inventor(s): Beth Tamburini, Jay Hesselberth, Shannon Walsh

Disease Areas Oncology

Category(s): Research Tools