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Device & Method for Monitoring Motor Responsiveness During Deep Brain Stimulation (DBS)
Background on CU5474H Deep brain stimulation (DBS) is commonly used for the treatment of movement disorders, such as Parkinson’s Disease. As part of awake DBS implantation surgery, neural activity is recorded from brain structures to aid in targeting specific anatomic regions. Features of the recorded neural activity (i.e. firing rate, waveform)...
Published: 6/7/2023   |   Inventor(s): John Thompson, Anand Tekriwal
Disease Areas Neurology, Surgery
Category(s): Medical Devices
Laminoplasty Distractor System
Cervical laminoplasty is a surgical procedure done by neurosurgeons or orthopedic spine surgeons for cervical spinal canal stenosis. The procedure is performed by opening the spinal canal to allow more room for the spinal cord while leaving the ligaments of the spine intact. There are many different techniques for laminoplasty. Dr. Dusty Richardson...
Published: 6/22/2023   |   Inventor(s): Marlin "Dusty" Richardson
Disease Areas Neurology
Category(s): Medical Devices
Reversible CaMKIIa knockout mouse model for screening therapeutic effects on negative schizophrenia symptoms and other conditions
CU investigators have created a reversible CaMKIIa knockout mouse model to study the effects of restoring CaMKIIa expression in adult animals. To generate the CaMKIIa knockout mouse, a loxP/neomycin cassette was inserted into the CaMKIIa gene. The research team then crossed the CaMKIIa knockout mice with a mouse line carrying an inducible Cre recombinase,...
Published: 10/23/2023   |   Inventor(s): K. Ulrich ("Ulli") Bayer
Disease Areas Neurology
Category(s): Research Tools
IP3R3-tauGFP mouse model for imaging and characterization of the microvillus cells in the olfactory epithelium
CU investigators have generated the IP3R3-tauGFP mouse model that expresses a fluorescent protein specifically in the microvillus cells of the mouse main olfactory epithelium (MOE). This mouse model was created by linking the IP3R3 promoter to the coding region of a tau-GFP fusion protein and inserted into the mouse genome. Researchers have used the...
Published: 5/22/2023   |   Inventor(s): Diego Restrepo
Disease Areas Neurology
Category(s): Research Tools
Immortalized Human Dopamine Cells to Improve Neurological Deficits / Fetal neurons as treatment for parkinson's disease
The implantation of fetal brain tissue has been used to treat patients with neurodegenerative diseases. The main limitations of fetal tissue in existing approaches are the lack of availability of appropriate aged tissue and the variability between specimens. To circumvent these inherent problems as well as additional social concerns, many groups have...
Published: 9/6/2023   |   Inventor(s): Kedar Prasad, Curt Freed
Disease Areas Neurology, Regenerative Medicine
Category(s): Therapeutics
Susceptibility Weighted Magnetic Resonance Imaging for Single-scan MR Angiography and Venography
Currently, magnetic resonance data for the imaging of arterial (MRA) and venous (MRV) vasculature must be acquired in separate scans. The time to perform either scan may be relatively long, causing patient discomfort as well as errors in data acquisition. Furthermore conventional MRV displays the vasculature at minimum intensity projection (MIP) leading...
Published: 8/30/2022   |   Inventor(s): Yiping Du
Disease Areas Neurology
Category(s): Medical Devices
Neuroprotective effects of metalloporphyrins against chemical threat agents
Oxidative stress as a therapeutic target for nerve agent toxicity. Researchers at the University of Colorado have defined oxidative stress as a mechanism of brain injury resulting from nerve agent and its surrogates. They have identified oxidative stress as an important therapeutic target for chemical agent-induced neurotoxicity and cognitive dysfunction...
Published: 6/19/2023   |   Inventor(s): Manisha Patel, Li-Ping Liang, Simon Waldbaum, John McManus
Disease Areas Emergency Medicine, Neurology, Neurology
Category(s): Therapeutics
Neuroprotective effects of metalloporphyrins against chemical threat agents
Oxidative stress as a therapeutic target for nerve agent toxicity. Researchers at the University of Colorado have defined oxidative stress as a mechanism of brain injury resulting from nerve agent and its surrogates. They have identified oxidative stress as an important therapeutic target for chemical agent-induced neurotoxicity and cognitive dysfunction...
Published: 6/19/2023   |   Inventor(s): Manisha Patel, Li-Ping Liang, Simon Waldbaum, John McManus
Disease Areas Emergency Medicine, Neurology, Neurology
Category(s): Therapeutics
A Shingles Vaccine That Does Not Reactivate
Researchers from the University of Colorado have developed mutated viral strains that only replicate under defined conditions and can be used as shingles vaccines. The inventors found that ORF 63 or 70 protein expression is required for shingles virus replication. They developed a viral mutant in which ORF 63 is deleted and ORF 70 protein is typically...
Published: 11/29/2023   |   Inventor(s): Ravi Mahalingam, Donald Gilden (Deceased)
Disease Areas Infectious Disease, Neurology, Neurology
Category(s): Therapeutics
A Shingles Vaccine That Does Not Reactivate
Researchers from the University of Colorado have developed mutated viral strains that only replicate under defined conditions and can be used as shingles vaccines. The inventors found that ORF 63 or 70 protein expression is required for shingles virus replication. They developed a viral mutant in which ORF 63 is deleted and ORF 70 protein is typically...
Published: 11/29/2023   |   Inventor(s): Ravi Mahalingam, Donald Gilden (Deceased)
Disease Areas Infectious Disease, Neurology, Neurology
Category(s): Therapeutics
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