Search Results - endocrine%2fmetabolism

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Novel Insulin B Chain Peptide to Prevent and Treat Type I Diabetes

Researchers at the University of Colorado have developed a mimotope of insulin B chain amino acids 9-23 (B:9-23) which shows a 100-fold better binding to the HLA-DQ8 molecule and allows for binding in a register that activates CD4 T cells in the nonobese mouse model of spontaneous autoimmune diabetes and human peripheral blood. This allows for the ability...

Published: 11/29/2023 | Inventor(s): Aaron Michels, George Eisenbarth (Deceased), John Kappler, Peter Gottlieb

Disease Areas Endocrine/Metabolism

Category(s): Therapeutics

Adenovirus Transducible 3T3-L1 Cells to advance genetic study of obesity

Genetic manipulation, altering native DNA or introducing foreign/exogenous DNA into cells, has proven to be an invaluable research tool to identify and study proteins integral in basic cellular function and disease but 3T3-L1 cells do not naturally lend themselves to the transfer (transduction) of genetic material. A research team led by James DeGregori...

Published: 12/1/2023 | Inventor(s): David Orlicky, James DeGregori, Jerome Schaack

Disease Areas Endocrine/Metabolism, Regenerative Medicine

Category(s): Research Tools

AMPD2 Inhibitors for Treatment/Prevention of Obesity, Diabetes, Metabolic Syndrome, Fatty Liver and Hypertension

Metabolic syndrome combines a variety of medical disorders including obesity, type 1 diabetes, insulin resistance, and refractory hypertension, all of which increase the risk of developing cardiovascular disease. A research group led by Dr. Richard Johnson has identified the use of a specific variant of adenosine monophosphate deaminase 2 (AMPD2) as...

Published: 11/30/2023 | Inventor(s): Richard Johnson, Gabriela Garcia, Christopher Rivard, Miguel Lanaspa-Garcia

Disease Areas Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Hematology

Category(s): Therapeutics

AMPD2 Inhibitors for Treatment/Prevention of Obesity, Diabetes, Metabolic Syndrome, Fatty Liver and Hypertension

Published: 11/30/2023 | Inventor(s): Richard Johnson, Gabriela Garcia, Christopher Rivard, Miguel Lanaspa-Garcia

Disease Areas Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Hematology

Category(s): Therapeutics

AMPD2 Inhibitors for Treatment/Prevention of Obesity, Diabetes, Metabolic Syndrome, Fatty Liver and Hypertension

Published: 11/30/2023 | Inventor(s): Richard Johnson, Gabriela Garcia, Christopher Rivard, Miguel Lanaspa-Garcia

Disease Areas Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Hematology

Category(s): Therapeutics

AMPD2 Inhibitors for Treatment/Prevention of Obesity, Diabetes, Metabolic Syndrome, Fatty Liver and Hypertension

Published: 11/30/2023 | Inventor(s): Richard Johnson, Gabriela Garcia, Christopher Rivard, Miguel Lanaspa-Garcia

Disease Areas Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Hematology

Category(s): Therapeutics

xMedical Monitoring System for Automatic Administration of Insulin and Other Medications

Dr. Peter Chase has developed a receiver-controller device that can receive a signal generated by a monitoring device and control the operation of a therapeutic substance delivery device based on the signal it receives from the monitoring device. The receiver-controller can be programmed for various warning conditions that can be calibrated to suit...

Published: 6/21/2023 | Inventor(s): H. Peter Chase

Disease Areas Endocrine/Metabolism

Category(s): Medical Devices

Micro RNAs that target metabolic enzymes and nutrient transporters in breast cancer

Patients with triple-negative breast cancer often have increased risk for recurrence and metastasis as well as decreased 5-year survival. Since triple-negative breast cancers don’t depend on hormone receptors or HER for growth, triple-negative cancers do not respond to hormone or HER dependent therapies. Jennifer Richer and her research team have...

Published: 11/30/2023 | Inventor(s): Jennifer Richer Mouchantat, Dawn Cochrane, Steven Anderson

Disease Areas Endocrine/Metabolism, Oncology

Category(s): Diagnostics

Connection to Health: Patient Self-Management Support System

Many payments for medical care are shifting from a flat fee for service to a value-based model . For many of these models, direct patient-provider interaction is a necessary fixture in reimbursement. However, electronic medical record (EMR) solutions are built for documentation and billing and do not support the type of collaboration needed for implementation...

Published: 6/9/2023 | Inventor(s): Bonnie Jortberg, Perry Dickinson, Douglas Fernald, Bruce Bender, Miriam Dickinson, Kyle Knierim, Robyn Wearner

Disease Areas Endocrine/Metabolism

Category(s): Software

Treatment of Metabolic Syndrome and Obesity with HDAC11 Inhibitors

Researchers at the University of Colorado have found that histone deacetylase 11 (HDAC11) inhibitors may be a treatment for metabolic syndrome and obesity-related conditions. In mice, they found that compared with wildtype (WT) controls, animals lacking HDAC11 were lean and displayed enhanced production of metabolically active BAT. HDAC11-deficient...

Published: 5/26/2023 | Inventor(s): Timothy McKinsey, Rushita Bagchi, Bradley Ferguson, Matthew Stratton

Disease Areas Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism, Endocrine/Metabolism

Category(s): Therapeutics

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